Esketamine is the newer drug in psychiatry with high efficacy. Esketamine (s-enantiomer of ketamine) was approved by the FDA on March 5, 2019, to treat treatment-resistant depression. Esketamine is delivered through nasal spray. Nasal spray is the fast-acting drug. It can be used to treat treatment-resistant depression. Each device contains 28 mg. Esketamine increases dopamine activity in the brain. It is contraindicated for patient with aneurysmal vascular disease, arteriovenous malformation, intracerebral hemorrhage, children, pregnant mothers, and lactating mothers.
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