Pondicherry Journal of Nursing

Register      Login

VOLUME 13 , ISSUE 2 ( April-June, 2020 ) > List of Articles

REVIEW ARTICLE

Darier's Disease

Kounassegarane Deepika

Citation Information : Deepika K. Darier's Disease. 2020; 13 (2):43-45.

DOI: 10.5005/jp-journals-10084-12138

License: CC BY-NC 4.0

Published Online: 13-08-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

A sparse inherited condition named Darier\'s disease (DAR), which was initially identified by a famous French dermatologist, Jean Darier, is caused by the defect in the mutation of the ATPA2 gene. Darier\'s disease is mainly represented by crusty dark patches over the skin, rarely with exudates, and it is otherwise termed as Darier\'s white patches, keratosis follicularis, keratotic papules, or dyskeratotic follicularis. It is an autosomal disorder, and it is tested by genetic testing registry, skin biopsy, and by means of obtaining a familial history. Around 90% of the cases are treated by oral retinoids and topical application. Remaining cases need a surgical repair. The person affected with this disease may have chances of getting mood disorders.


PDF Share
  1. Ringfeil F. Darier disease. NORD Guide to Rare Disorders. Philadelphia, PA: Lippincott Williams & Wilkins; 2003. p. 101.
  2. Rimoin D, Connor JM, Pyeritz RP, Korf BR. Emory and Rimoin's Principles and Practice of Medical Genetics. 4th ed., New York, NY: Churchill Livingstone; 2002. pp. 3913–3915.
  3. Champion RH, Burton JL, Ebling FJG. Textbook of Dermatology. 5th ed., London, UK: Blackwell Scientific Publications; 1992. pp. 1362–1365.
  4. James WD, Berger TG, Elston DM. Andrew's Diseases of the Skin: Clinical Dermatology. 10th ed., Saunders; 2005. pp. 567–568.
  5. Byrne CR. The focal nature of Darier's disease lesions: calcium pumps, stress, and mutation? J Invest Dermatol 2006;126(4):702–703. DOI: 10.1038/sj.jid.5700141.
  6. Ringpfeil F, Raus A, DiGiovanna JJ, Korge B, Harth W, Mazzanti C, et al. Darier disease–novel mutations in ATP2A2 and genotype-phenotype correlation. Exp Dermatol 2001;10(1):19–27. DOI: 10.1034/j.1600-0625.2001.100103.x.
  7. Sehgal VN, Srivastava G. Darier's (Darier-White) disease/keratosis follicularis”. Int J Dermatol 2005;44(3):184–192. DOI: 10.1111/j.1365-4632.2004.02408.x.
  8. Apadin AN, Fleischmajer R. Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol 2006;54(2): 258–265. DOI: 10.1016/j.jaad.2005.10.004.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.