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VOLUME 14 , ISSUE 1 ( January-March, 2021 ) > List of Articles

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A Miracle Drug for Tuberculosis: Bedaquiline

Subakeerthi Venkataramanan, Renuka Kandasamy

Keywords : Bedaquiline, Diarylquinolines, Extensively drug-resistant tuberculosis, Multidrug-resistant tuberculosis, Mycobacterial adenosine 5′-triphosphate synthase

Citation Information : Venkataramanan S, Kandasamy R. A Miracle Drug for Tuberculosis: Bedaquiline. 2021; 14 (1):23-24.

DOI: 10.5005/jp-journals-10084-12174

License: CC BY-NC 4.0

Published Online: 01-03-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

A new tuberculosis (TB) medication includes the active ingredient bedaquiline. Sirturo is a brand name for a drug that belongs to the diarylquinoline class of drugs. Bedaquiline is a diarylquinoline antimycobacterial drug that works by blocking an enzyme within the bacteria that cause TB. It prevents the proton pump of mycobacterial adenosine 5′-triphosphate (ATP) synthase. Bedaquiline is metabolized in hepatic form and eliminated in the feces. Bedaquiline is effective and safe in treating multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) patients. This drug treatment regimen was well supported and tended to a good result in this clinically relevant patient associated with MDR-TB.


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