Background: Pressure ulcers are a type of injury that breaks the skin and underlying tissue. Among patients, it increases the discomfort, cost of treatment specifically for pressure ulcer. The treatment modalities of pressure ulcer include skin assessment, reposition, and skin massages. Aims and objectives: This paper aims to assess the risk score of pressure ulcer among immobilized patients, evaluate the effectiveness of Vibration Effleurage Petrissage MASsager (VEPMAS) device on prevention of pressure ulcer, and associate the risk of pressure ulcer among immobilized patients with selected demographic variables. Methods: Quantitative research with true experimental research design was adopted for this study. One hundred samples (50 in control group and 50 in experimental group) were selected using simple random sampling technique. Pretest was done in both groups using structured questionnaire for demographic variables and pressure ulcer risk using Braden Scale. VEPMAS device was applied to experimental group, and routine nursing care was given to control group. Posttest was done using Braden Scale in both the groups. Results: The study result shows that experimental group posttest mean score of risk of pressure ulcer was 13.9 ± 1.705, whereas in control group 13.4 ± 1.498. This shows VEPMAS device was most effective than manual back massage in preventing pressure ulcer among immobilized patients. Conclusion: A simple and effective method of preventing the pressure ulcer will be skin massage. Thus the study finding shows VEPMAS device was effective than routine nursing care.