Background: All people need their formative years because they lay the foundation for their personalities and emotional resilience throughout this time. All children, regardless of age or nationality, are being impacted by the coronavirus disease-2019 (COVID-19) global problem. The impacts may be lifelong for some young people. In this difficult moment, let's all pledge to do everything in our power to mitigate COVID-19's effects on the children, who most urgently require protection. Objectives: To evaluate the effectiveness of a structured teaching program in terms of improvement in knowledge regarding COVID-19 in children among BSc Nursing students. Materials and methods: It was a preliminary experiment carried out at Virudhunagar's V. V. Vanniaperumal Nursing College for female students. The tool, a self-structured knowledge questionnaire, was used to evaluate the success of structured education programs as well as the degree of knowledge. This study employed a pre-experimental research approach and purposive sampling. Results: It was discovered that the acquired “t” value of 14.98 is statistically significant at the 0.05 level and that the obtained mean posttest knowledge score of 20.78 is greater than the obtained mean pretest knowledge score of 15.38. The study's findings suggest that the organized training program was successful in enhancing BSc nursing students’ knowledge of COVID-19 in children. Conclusion: All youngsters receive health maintenance during the COVID-19 epidemic from healthcare professionals. The study indicated the need for BSc Nursing students to get efficient in-service training on COVID-19 in children.