Background: Acute myocardial infarction (AMI) is a medical emergency and the most deadly presentation of coronary heart disease. The concept of golden hours is extremely crucial because most deaths and cardiac arrests occur during this period. Golden hours is a window of opportunity that has an impact on a patient's survival and quality of life. Aim: This study aimed to assess the facilitators, barriers, and outcomes of timely treatment in golden hours for patients with myocardial infarction (MI). Materials and methods: A descriptive correlational study design was carried out among 100 patients with MI at the selected tertiary care center, selected by consecutive sampling technique. The data collection was done using pretested and predetermined tools such as background variables pro forma, and checklist to assess the facilitators, barriers, and outcomes of timely treatment in golden hours for patients with MI. The collected data were analyzed by using descriptive and inferential statistics. Results: The study findings showed that there was a significant association between timely treatment and source of information on MI (χ² = 5.555, p < 0.05), history of hypertension (χ² = 5.787, p < 0.05), the outcome of a patient with MI such as survival rate of the patient (χ² = 4.21), need for medical management (χ² = 2.68), coronary artery bypass graft (CABG) (χ² = 22.33), percutaneous transluminal coronary angioplasty (PTCA) (χ² = 9.071), intra-aortic balloon pump (IABP) (χ² = 11.26), length of stay (LOS) (χ² = 41.67), recurrence of cardiac arrest (χ² = 18.34), and dysrhythmia (χ² = 28.51) at p < 0.05 level. Conclusion: Hence the study showed that delay in seeking treatment for MI symptoms limits the benefits of reperfusion therapies and influences the prognosis of treatment.