Introduction: God has created human beings as equal without any discrimination as to their skill power, will power, grasping power, intellect, etc. But it's the human beings who discriminate, misuse and abuse human being and treat them as objects and the fault lies only on the selfish nature of the human beings. Aim and objective: To assess the quality of life among transgenders residing at Puducherry. To correlate the quality of life and general health among transgender with their demographic variables. To associate the quality of life among transgender with their demographic variables. Methodology: The present study was conducted to “a descriptive study.” A quantitative research approach was considered as appropriate for the present study. The investigation (research) design selected for the study is descriptive design. The study was conducted in Puducherry. The selection of setting was done on the basis of feasibility of conducting the study. The target population for the study comprises transgenders at Puducherry in this present study. Sample consists of 100 transgenders in Puducherry. Purposive sampling technique was used to select the samples of this study modified World Health Organization Quality of Life, Health, Physical, Psychological, Social and Environmental (WHOQOL-BREF) and General health questionnaires (GHQs) on quality of life among transgenders residing at Puducherry. Demographic data consist of age in years, religion at birth, religion at present, educational status, occupation, income, type of family, relationship status, residing area, whether they are living with their family, when did you feel that you are not belonging to biological gender, age at which left home, did you undergo cosmetic/surgical changes, at which age you underwent cosmetic/surgical change made. Results: It shows that out of 100 transgenders highest percentage of 86 (86%) were of fair health and 12 (12%) were better health and 2 (2%) were worst health.