Background: Cardiopulmonary resuscitation (CPR) is an emergency treatment meant to save the life of a person experiencing cardiac arrest. It is evident in persons who are breathing only gasps or are unconscious. It can be tried both inside and outside of a medical facility. The study's goals were to evaluate the staff nurses’ degree of knowledge about CPR and the demographic variable. Materials and methods: There was use of a quantitative descriptive research design. Among the population are staff nurses employed by SLG Hospitals in Hyderabad. Using the convenient sampling technique, 30 samples of staff nurses who met the inclusion criteria were chosen from among them. Nurses with a year of experience at SLG Hospital, who speak Hindi, English, and Telugu, as well as those who are open to taking part in the research were included in the study. Experts validated the tool, and prior authorization was secured to carry out the investigation. Consent was gained with knowledge. The investigator guaranteed privacy. A pilot research was carried out. The questionnaire technique was used to collect the data. A semi-structured questionnaire was used to assess the respondents’ knowledge of CPR. Descriptive statistics was used to plan the data analysis. Findings: The findings showed that staff nurses’ knowledge of CPR was divided into three categories: inadequate knowledge (13.3%), somewhat adequate knowledge (76.6%), and adequate knowledge (10%).