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VOLUME 9 , ISSUE 1 ( Jan-April, 2016 ) > List of Articles

RESEARCH ARTICLE

Abnormal Cholesterol Uptake Rate Of Leucocytes Reflecting Metabolic Aberration In Non Insulin Dependent Diabetes Mellitus With lschem1c Heart Disease Patients

Jayanthi Rajendran, Sumathy Kumar

Keywords : Type 2 Diabetes Mellitus, Glycated hemoglobin, Dyslipidemia, Cardiovascular

Citation Information : Rajendran J, Kumar S. Abnormal Cholesterol Uptake Rate Of Leucocytes Reflecting Metabolic Aberration In Non Insulin Dependent Diabetes Mellitus With lschem1c Heart Disease Patients. 2016; 9 (1):25-29.

DOI: 10.5005/pjn-9-1-25

License: CC BY-NC 4.0

Published Online: 01-04-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Objectives- To assess the lipid and lipoprotein abnormalities, oxidative stress, the effect of antioxidant defences to protect the beta cells from glucotoxicity and also to assess the uptake of cholesterol avidly by the normal lymphocyte cells, diabetic and diabetic with Ischemic heart diseases(IHD) cells. Method-: 60 clinically diagnosed cases of type 2 diabetes mellitus with the age range 30-75 years were included in the study group. Out of which 30 diabetic patients with good glycemic control were included under Group I with age and sex matched healthy individuals served as controls and 30 diabetic patients with/without complications were included under Group II & III. Results: The fasting blood glucose were significantlyhigher in (p<.001) when compared with controls and parallel increase is seen in HbAlC in group I/&III. Similar trend is observed in triglycerides and free fatty acids. Lipid peroxidation levels increases nearly five fold in diabetic patients with/HD. SOD, CAT activities are low while GPx level is raised with increased DNA strand breakage in group II. Conclusion- In conclusion, with progression of diabetes, i.e development of complications shows increase in fa sting blood glucose, cholesterol distribution in lipoprotein, lipid per oxidation and role of antioxidants.


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