In this article, pain due to musculoskeletal disorders is often regularly ignored by the general public; however, it is one of the most significant reasons for weight to the general public as far as incapacity around the world. The present investigation is meant to evaluate the degree of torment in musculoskeletal issue through evidence-based research. Cold and compression are routinely applied or immediately after acute injury to help in relieving pain, and it will reduce swelling and speed functional recovery. Literature review is to describe the published clinical findings regarding combined cold and compression therapy in the management of pain in musculoskeletal disorders. Cold compression therapy provides better outcomes such as pain relief compared to alternative interventions. The efficacy of oxygen-compressed cold application in pain reduction in patients with musculoskeletal disorders was also studied. These observations have resulted in technological advances directed toward combining these modalities in an effort to effectively manage and prevent musculoskeletal injury and disorders. In this review, the scientific basis for thermal-based therapeutic modalities, both alone and in conjunction with soft-tissue massage and compression, will be discussed. Additionally, the advantages of the effective device for the treatment and prevention of pain among patients with musculoskeletal disorders will be considered.
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