Idiopathic fatal pancytopenia is a rare disease with a grave prognosis. Pancytopenia is defined as reduction in all three types of blood cells, such as erythrocytes, leukocytes, and thrombocytes. Erythrocytes transport oxygen to parts of our body; leukocytes play a major role in our body by fighting against infection and destroying pathogens; thrombocytes act as primary agents to stop bleeding at the site of injury. Pancytopenia predisposes to increase the chances of infection and bleeding tendencies.^1–3 A 41-year-old female client got admitted in a hospital with the signs and symptoms of giddiness, bleeding per vagina for 20 days, breathlessness on exertion, generalized body weakness, vomiting, and pain abdomen. There were no abnormal findings on physical and systemic examination. Complete blood count (CBC) findings showed decreased number of all three kinds of cells, whereas other hematological parameters were normal. Stool examination revealed presence of occult blood with no abnormal findings on ultrasonography (USG). On bone marrow examination, hypercellular bone marrow was seen with reduction of all three blood cells. Patient was admitted in hospital for 20 days. The cause of pancytopenia remained unexplained. Following administration of blood and blood products, inotropes and hematinic therapy led to the recovery of the blood cell components to normal level. Bone marrow examination later became normal. Idiopathic fatal pancytopenia is a rare condition based on clinical and pathological features.