The most prevalent external fixator consequence is pin-site infection. Pin-site infections increase the frequency of hospital visits needed during a patient's therapy and may necessitate extra treatment, such as antibiotics and surgery. In comparison with other series from affluent and developing nations, there is a significant frequency of pin-tract infections after external fixation for fracture. Aims and objectives: • To assess the pin-site infection among patients with external fixators. • To evaluate the effectiveness of multicomponent nursing care on pin-site infection among patients with external fixators. • To find out the association between multicomponent nursing care on pin-site infection among patients with external fixators and their selected demographic variables. Materials and methods: This study took a quantitative research technique. This study used a two-group pretest and posttest design. Using a simple random sampling procedure, 60 samples were selected and divided into two groups. Pretest and posttest use Checketts and Otterburn grading system, as well as an assessment of pin-site infection. On pin-site infection among patients with external fixators and their specified demographic factors, multicomponent nursing care was given to experimental group I and routine care was given to control group II. Results: According to the data of the 60 participants in group I (experimental), 26 (86.7%) had no pin-site infection, while 4 (13.3%) had minor pin-site infection, and 0 (0%) had major pin-site infection of external fixators. In group II (control), 2 (6.7%) had no pin-site infection 28 (93.3%) had minor pin-site infection and 0 (0%) had major pin-site were having minor pin-site infection. And the p-value of 0.005^* indicates that the result is statistically significant. As a result, H₁ and H₂ were accepted. In patients with external fixators, the effectiveness of multicomponent nursing care on pin-site infection is reduced.