Aim: Nurses play a major role in caring for patients in the coronavirus disease-2019 (COVID-19) ward. Hence, the nurse should be updated and gain knowledge regarding COVID-19. So, the current study was carried out to assess the level of knowledge and attitude regarding COVID-19 care among staff nurses who were working in COVID-19 wards. Objectives: (A) To assess the level of knowledge regarding COVID-19 care among the staff nurses working in the COVID-19 ward; (B) To assess the level of attitude regarding COVID-19 care among staff nurses working in the COVID-19 ward; (C) To find out the association between the selected demographic variables and the level of knowledge and attitude among staff nurses working in the COVID-19 ward. Methodology: Non-experimental descriptive design was used to assess the level of knowledge and attitude of staff nurses worked in COVID-19 ward. Fifty samples were selected by using purposive sampling technique. Results: On assessing of knowledge score of staff nurses who provided care in COVID-19, 14% of them had adequate knowledge in the range of 16–20, 74% of staff nurses had moderate knowledge between the range of 11–15, and 12% of staff nurses had the inadequate knowledge between the range of 0–10. On assessing the attitude of staff nurses who provided care during COVID-19, 46% of staff nurses had a satisfactory attitude, 40% of staff nurses had a desirable attitude, 4% of staff nurses had an unsatisfactory attitude, and 10% of staff nurses had undesirable attitudes. The mean knowledge score was 13.38, the standard deviation was 0.4, the mean attitude score was 7.28, and the standard deviation was 0.6. Conclusion: The study concluded that from the basis of the findings, the staff nurses had a moderate knowledge of COVID-19 care and also had a desirable attitude toward COVID-19 care.